Stress Therapy Solutions Educational Information Resource
Search:     Advanced search
Browse by category:
Contact Us

A neurophysiological insight into the potential link between transcranial magnetic stimulation, thalamocortical dysrhythmia and neuropsychiatric disorders

Views: 2736
Votes: 0
Posted: 15 Oct, 2012
by: Admin A.
Updated: 06 Mar, 2014
by: Admin A.

by Fuggetta et al

 

Abstract

Altered neural oscillations and their abnormal synchronization are crucial factors in the pathophysiology of several neuropsychiatric disorders. There is increasing evidence that the perturbation with an abnormal increase of spontaneous thalamocortical neural oscillations lead to a phenomenon termed Thalamocortical dysrhythmia (TCD) which underlies the symptomatology of a variety of neurological and psychiatric disorders including Parkinson's disease, schizophrenia, epilepsy, neuropathic pain, tinnitus, major depression and obsessive-compulsive disorder. In addition, repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurophysiological tool that has been shown to both induce a modulation of neural oscillations and alleviate a wide range of human neuropsychiatric pathologies. However, little is known about the precise electrophysiological mechanisms behind the therapeutic effect of rTMS and its potential to improve abnormal oscillations across diverse neuropsychiatric disorders. Here we show, using combined rTMS and surface electroencephalography (EEG), a short lasting frequency-dependant rTMS after-effect on thalamocortical rhythmic interplay of low-frequency oscillations in healthy humans at rest. In particular, high-frequency rTMS (10 Hz) induces a transient synchronised activity for delta and theta rhythms thus mimicking the pathological TCD-like oscillations. In contrast, rTMS 1 and 5 Hz have the opposite outcome of de-synchronising low-frequency brain rhythms. These results lead to a new neurophysiological insight of basic mechanisms underlying neurological and psychiatric disorders and a probable electrophysiological mechanism underlying the therapeutic effects of rTMS. Thus, we propose the use of rTMS and EEG as a platform to test possible treatments of TCD phenotypes by restoring proper neural oscillations across various neuropsychiatric disorders.

 

Attached files
file Fuggetta.pdf (708 kb)

Others in this Category
document Case Studies using Live Z-Score Training - Journal of Neurotherapy
document Case Report - Z-Score practitioner Tom Brown comments re. ASD
document Orlando and Rivera article on Learning Disabilities
document QEEG-Guided Neurofeedback for Children with Histories of Abuse and Neglect: Neurodevelopmental Rationale and Pilot Study
document Case Report - Live ZScore training post-stroke
document Gevensleben articles on Neurofeedback for ADHD
document Brown University Progress Report - Alzheimer's and Live Z-Score Training
document Duke University report on ADHD and Neurofeedback - Long Term Effects
document Insomnia and Live Z-Score Training Results from Dr. Barbara Hammer
document EEG Biofeedback and Cognitive Rehabilitation for Traumatic Brain Injury
document Ultra-Low Frequency Training - Clinical Comment
document Antidepressant Efficacy Evaluated in Psychotherapy and Psychosomatics - Pigot, Leventhal, Alter, Boren - NeuroAdvantage and American University
document QEEG-Guided Neurofeedback for Recurrent Migraine Headaches - Dr. Jonathan Walker NEW PRESS RELEASE
document Brownback Mason and Associates: NeuroConections Spring 2011
document Brainclinics study on QEEG-based treatment in ADHD
document EEG Spectral coherence data distinquish chronic fatigue syndrome patients from healthy controls and depressed paitents
document Spontaneous Brain Activity Relates to Autonomic Arousal
document Emergence of Stable Functional Networks in Long-Term Human Electroencephalography
document Peri-ictal and interictal, intracranial infraslow activity
document Cerebral electromagnetic activity in the subdelta range
document Recovery of the default mode network after demanding neurofeedback training occurs in spatio-temporally segregated subnetworks
document Evidence-Based Information on the Clinical Use of Neurofeedback for ADHD
document Good vibrations: Oscillatory phase shapes perception
document Neurocognitive networks: Findings, models, and theory
document Clinical utility of paced breathing as a concentration meditation practice
document Alpha power, alpha asymmetry and anterior cingulate cortex activity in depressed males and females
document Self-regulation of brain oscillations as a treatment for aberrant brain connections in children with autism
document The emergence of abnormal hypersynchronization in the anatomical structural network of human brain
document Neurofeedback for the treatment of children and adolescents with ADHD: a randomized and controlled clinical trial using parental reports
document Neurofeedback Training for Relieving Auditory Hallucinations: How Should Neurofeedback Be Applied to AVHs? 4 Hypotheses
document EEG Coherence between prefrontal and posterior cortical regions is related to negative personality traits
document Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)
document Tracking EEG changes in response to alpha and beta binaural beats
document Studying the topological organization of the cerebral blood flow fluctuations in resting state
document Cognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging
document Anatomical connectivity and the resting state activity of large cortical networks
document Rethinking Autism: Variation and Complexity
document The Development of Hub Architecture in the Human Functional Brain Network
document How the brain controls our habits
document Amygdala Volume Changes in Posttraumatic Stress Disorder in a Large Case-Controlled Veterans Group
document The Peniston-Kulkosky Brainwave Neurofeedback Therapeutic Protocol: The Future Psychotherapy for Alcoholism/PTSD/Behavioral Medicine
document Use of normative databases and statistical methods in demonstrating clinical utility of QEEG: importance and cautions.
document Diagnostic approach to children with minor traumatic brain injury
document A QEEG index of level of functional dependence for people sustaining acquired brain injury: the Seville Independence Index (SINDI)
document Thalamic shape and connectivity abnormalities in children with attention deficit/hyperactivity disorder
document Adaptive Resonance Theory: How a brain learns to consciously attend, learn, and recognize a changing world
document Altered Functional Brain Connectivity in a Non-Clinical Sample of Young Adults with Attention-Deficit/Hyperactivity Disorder
document Anti-Aging Research using Neurofeedback - T. Collura
document Dyslexia and Dysgraphia Neurofeedback Studies by Jonathan Walker and others
document The Effectiveness of Neurofeedback Training on EEG Coherence and Neuropsychological Functions in Children With Reading Disability
document One Size Fits All? Slow Cortical Potentials Neurofeedback: A Review
document Reading and Writing Disorders - QEEG and Neurofeedback
document NeuroConnections Winter 2012 Articles
document Meditation, EEG Research
document American Academy of Pediatrics
document Depression and Neurotherapy References
document Infra-slow fluctuations in heart and brain
document Infra-slow EEG oscillations and brain oxygen
document Cantor Tuttle International Pharmaco-EEG Group October 2012, New York
document Neurofeedback: A Promising Treatment for Depression
document Neurofeedback Training Induces Changes in White and Gray Matter
document Head Injury and EEG, QEEG, and Neurofeedback References
document American Academy of Pediatrics Evidence-Based Psychosocial Interventions
document Neurofeedback for memory improvement
document Dyslexia assessment intake QEEG maps
document Recent Publications on Neurofeedback



RSS